Army’s Vaccine Plan: Inject Troops With Gas-Propelled Electro-Charged DNA

Wired

The Army’s got a one-two punch to perfect vaccinations and offer scientists the ability to quickly develop inoculations that stave off new dangers. First, they’ll shoot troops up using a “gene gun,” that’s filled with DNA-based vaccines. Then they’ll follow it up with “short electrical pulses to the delivery site.”

The Pentagon’s still after a comprehensive way to inoculate troops and civilians against existing illnesses, rapidly respond to emerging threats, and even predict pathogenic mutations before they happen. To that end, the military’s already funding a handful of projects, from plant-based vaccine production to genetic signatures for ultra-early diagnosis.

In a small business solicitation released last week, the Army put out a call for “Multiagent Synthetic DNA Vaccines Delivered by Noninvasive Electroporation.” The program would start by transforming conventional development methods, like standard egg-based vaccines.

The old-school methods are slow, don’t allow for readily combined vaccines, and can pose sterility risks. DNA-based vaccines, on the other hand, would be quick to engineer and offer reliable immunity — provided the DNA can enter host cells to trigger the production of immunity proteins.

Right now, DNA-based vaccines are injected into muscles, meaning a genetically engineered plasmid is delivered to “intracellular spaces,” and “is not efficiently taken up by the host cells.” So the Army would instead like to shoot people. Seriously.

In its solicitation, the Army says it wants DNA vaccines that are painted onto microscopic beads, then “deposited into skin cells by gas propulsion.” And since that method can only inject a small dose of DNA, they want researchers to combine the approach with intramuscular electroporation, which “involves injecting the DNA then quickly applying short electrical pulses.” The electric charge creates pores in cell membranes, making it easier for DNA to enter targeted cells.